In order to prevent the inrush damage of deep base pit in high confined water stratus, relying on the deep base pit of Well GX12 of the follow-up optimization project of Jinjiang-Rongjiang-Liujiang water system connection, the three-dimensional numerical model is established by finite element software, and five technical schemes considering the depth of the slurry wall and the laying of the pressure reducing well are simulated and analyzed, the anti-inrush effect of each scheme is studied, and the optimization scheme of anti-inrush of pit engineering is determined by comprehensively considering the anti-inrush effect of the base pit, the technical difficulty of the construction of the slurry wall and the engineering cost. The results show that: 1) The depth of the slurry wall can be optimized from the original design of 91.8 m to 78 m; 2) The addition of a pressure reducing well in the base pit can effectively reduce the horizontal displacement of the pit bottom uplift and the slurry wall, however, the surface settlement around the base pit is increased, and the surface settlement and pit bottom uplift can be significantly reduced by increasing the depth of the slurry wall; 3) The anti-inrush effect of increasing the depth of the slurry wall is better than that of increasing a pressure reducing well. The results can provide some reference for the anti-inrush technology of deep base pit engineering in similar high-confined water stratum.