In order to explore the relationship between the relaxation degree of wind turbine anchor bolts and fatigue damage of foundationally local compressed concrete, an integral solid wind turbine foundation model is constructed with the help of ABAQUS software to simulate the development process of anchor bolt relaxation. The local compression analysis of concrete is explained by static loading, and the stress distribution and variation law of local concrete under fatigue load are revealed. The fatigue life of local concrete is evaluated by the concrete fatigue calculation method in the specification recommended by Germanischer Lloyd. The results show that: 1) The loosening of the anchor bolts in the wind turbine foundation significantly affects the stress distribution of the surrounding concrete, especially the stress concentration in the leeward direction is more prominent, and as the anchor bolts loosen further, the stress level increases accordingly. Therefore, monitoring the stress condition of the concrete on the leeward side can be an effective means to evaluate the loosening of the anchor bolts; 2) Comprehensive analysis of the fatigue compressive strength and expected fatigue life of the wind turbine foundation concrete shows that, when the anchor bolts loosen to a certain extent, the probability of concrete crushing failure is high. Therefore, the loose anchor bolts should be readjusted in time to prevent further deterioration of the anchor bolts. The results can provide data support for the safe operation and maintenance of actual projects.