There are multiple confined aquifers buried in different depths under the soft soil foundation in Suzhou city,and local engineering excavation has entered the confined aquifer. It has a great impact on the surrounding environment and requires strict deformation control. Therefore,how to effectively control the deformation of foundation pit is very important in the excavation of ultra?deep and super?large foundation pit in the soft soil foundation with high groundwater level. This paper takes the deep foundation pit project in the central South of Suzhou as the research object,and adopts the construction method of large and small,zoning and stratification in general. It is divided into 3 large areas and 20 small areas. The construction sequence of 3 large areas is rationally arranged by the construction method of combination of forward and backward. According to the asymmetric foundation pit of Suzhou Zhongnan Center,symmetrical excavation and skip construction are adopted. The time?space effect is realized through time?limited excavation,time?limited support,warehouse jumping construction and zoning water flow. Through information monitoring and monitoring data,fine precipitation pressure reduction,soil reinforcement and other auxiliary means,the construction is dynamically guided. The maximum cumulative value of pit wall slope monitoring is 54.07 mm;The maximum cumulative value of the settlement of the surrounding buildings is 15.61 mm,which always keeps the foundation pit in a safe and controllable state.