Fluorite, as an indispensable strategic reserve mineral resource, plays a supporting role in the development of fluorine chemical industry in China. With the increasing demand and consumption of acid-grade fluorite ( CaF₂? mass fraction not less than 97% ) and the gradual scarcity of high-grade and high-quality fluorite resources, it is of great significance to study the process of efficiently developing and utilizing fluorite resources to prepare high-purity acid-grade fluorite. In this paper, a low-grade fluorite mine is taken as the object to carry out an experimental study on the beneficiation and preparation process of acid fluorite powder, the effects of grinding fineness, collector, inhibitor, regulator and flotation process on the beneficiation preparation of acid fluorite powder is explored, and high-purity acid fluorite products are obtained through advanced scientific beneficiation technology. The results show that sulfide ore is removed by fluorite ore through pre-flotation, and the selected sulfide ore can be separated by one rough separation to obtain lead-zinc concentrate. The fluorite is recovered from the desulfurization tailings through the process of "1 coarse 3 sweeps-coarse concentrate re-grinding-8 times of selection", and the fluorite concentrate with CaF₂? mass fraction of 97.70% and fluorite recovery rate of 92.21% are finally obtained, which improves the added value of fluorite concentrate products. The results provide a technical basis for the overall efficient utilization of such resources.