To investigate the stability of slopes with prestressed anchor anti slip piles under different parameters, based on a certain slope project, finite element software Midas GTS NX is used to simulate the design parameters of anti slip piles. The influence of the cross-sectional size, pile spacing, and pre stress changes of prestressed anchor anti slip piles on slope stability is analyzed. The results indicate that prestressed anchor anti slip piles can improve slope stability, and the slope stability using the support scheme increased from 1.02 to over 1.30. By simulating the working conditions of different parameters of anti slip piles, it is found that the stability of slopes increases with the increase of the cross-sectional size of anti slip piles, the decrease of pile spacing, and the increase of anchor cable prestress, and vice versa; The increase of anchor cable prestress will improve the stability of the slope to a certain extent, but the growth amplitude of slope stability is gradually decreasing. When the anchor cable prestress continues to increase, its contribution to slope stability will gradually decrease. The results of this article can provide some reference and guidance for the selection of design parameters for prestressed anti slip pile slopes.