In order to ensure the structure safety and maintain the normal operation of the cable-stayed bridge, it is inevitable to replace the cable during its service. However, the removal of the cable-stayed cable will lead to structural changes, and different cable replacement schemes will directly affect the safety of the cable replacement construction process. Based on the concept of zoning optimization, considering the cable length and the cable force, the cable-stayed bridge is partitioned, and according to the sensitivity performance of each cable replacement scheme in different areas, the index with higher sensitivity is selected as the evaluation basis, and the scheme is compared and selected in each area in combination with the construction efficiency. The results show that: 1) In the process of cable replacement, the deviation of the tower, the deflection of the main beam and the replacement of cable force are more sensitive, while the stress of the main tower and the main beam shows a lower sensitivity. 2) The cable force in the long cable area and the medium long cable area is large, and the impact of cable replacement on the structure is significant, and the construction risk is high. The cable force in the short cable area is small, and the impact of the cable replacement on the structure is relatively low. The results can provide certain references for the determination of the cable replacement scheme and the construction of the cable replacement.