In order to meet the needs of high-rise prefabricated buildings, a new type of prefabricated steel plate-concrete combined shear wall with inner steel pipe is proposed. The shear wall not only has excellent seismic properties, but is also easy to transport and assemble. The finite element software ABAQUS is used to conduct numerical simulation and comparison analysis of the prefabricated steel plate-concrete combined shear wall and ordinary double steel plate-concrete shear wall of the inner steel pipe, and the influence of each parameter on the seismic resistance of the prefabricated steel plate-concrete combined shear wall of the inner steel pipe is studied. The results show that: 1) Compared with ordinary double steel plate-concrete combined shear walls, the horizontal bearing capacity of the prefabricated steel plate-concrete combined shear wall (CSW3 specimen) with inner steel pipes is increased by 26.9% , and the energy consumption capacity is increased by 28.6% , which has higher bearing capacity and better seismic resistance; 2) Under the high axial pressure ratio, the new shear wall still maintains a good horizontal bearing capacity; 3) Reducing the steel pipe spacing can improve the energy consumption capacity of the new shear wall; 4) Reducing the shear span ratio can improve the load capacity and overall stiffness of the new shear wall, but the energy consumption capacity has been reduced. The results can provide a certain reference for the construction and development of high-rise prefabricated buildings in the future.