In order to reduce the harm caused by groundwater buoyancy to buildings, a new construction method of fully bonded prestressed anti-floating anchors is proposed by combining the characteristics of non-prestressed full-length bonded anti-floating anchors and prestressed anti-floating anchors. In this method, the prestressed steel bar, the prestressed section structure of the raft, the waterproof layer and the following fully bonded section structure are adopted, and the secondary grouting technology is combined. The anchor rod section in the raft is a prestressed section, and the prestressed tendon is anchored into the raft after tensioning; The anchor section below the waterproof layer is a fully bonded section, and the secondary grouting technology is adopted in the fully bonded section; The bottom plate of the raft is waterproof, and five waterproof seals are used at the position of the anti-floating anchors. Compared with the traditional anti-floating bolts, this method can reduce the amount of reinforcement, save labor costs, improve construction efficiency, and greatly shorten the construction period, so it is especially suitable for building structures with low groundwater level but high anti-floating requirements. It has been proved that this method performs well under the above conditions, which can provide a useful reference for such projects.