The consumption and resource utilization of mud shield muck is of great engineering significance. In order to study the feasibility of shield muck as road filler, based on the mud shield project in the water resources optimization allocation project in eastern Guangdong, combined with a large number of statistical analysis of research data and laboratory tests, the general physical properties of unchanged shield muck and the strength parameters of different particle sizes after curing by various curing methods are summarized, and the corresponding index requirements of each structural layer of the subgrade pavement are compared and analyzed, and then the corresponding recommended mix ratio of the curing agent is proposed. The results show that the solidifying agent based on cement and mineral powder can be used to solidify the sand muck soil, which can be used in the base layer of high-grade roads and the base layer of secondary highways. The solidified clay muck such as cement and quicklime (or fly ash) can be applied to the subbase layer of secondary highway and the roadbed of road engineering, and the results can provide references for the application of shield muck inorganic binders in road engineering.