In order to solve the problem of obvious deformation of surface structures and poor spreading effect of slurry during the construction of grouting reinforcement in saturated fine sand strata, taking Guangzhou metro line 13 Xiba station project as the research background, on-site experimental comparative research is carried out on the optimization of the construction process of grouting reinforcement of water-rich sand strata and the applicability of grouting reinforcement materials. The results show that: 1) the use of horizontal drilling rod backward grouting process, in the periphery of grouting holes to set up pressure relief holes for vacuum suction, grouting pressure and drainage pressure under the joint action of the grouting pressure can be realized under the direction of the induced infiltration of grouting; 2) in the ultra-fine cement to add water reducer can enhance the penetration capacity of the slurry, the same conditions of the grouting pressure, the addition of $0.4\%$ of the single-hole grouting volume than the addition of a single-hole grouting volume of the single-hole grouting volume of the water reducer to increase by 4 times; on-site monitoring results show that the use of The field construction monitoring results show that the grouting by "pumping method" can effectively control the deformation of the surrounding strata without increasing the grouting pressure, and the uplift deformation values of the ground surface and pipeline are controlled within 1cm . The results of this paper can provide certain reference for similar projects.