Perforated aluminum panel is a new type of exterior decorative material. In order to ensure its normal use in strong wind environment, it is essential to study its wind resistance performance. In this paper, by means of the method in combination of experimental verification and finite element numerical simulation, the perforated aluminum panels commonly used in engineering are systematically studied for the influence of different perforation spacings, perforation diameters, and perforation rate on the deformation characteristics, stress distribution, and overall wind resistance performance of the perforated panels. The results show that, under constant perforation spacing and a fixed perforation rate, an increase in perforation diameter leads to a slight upward trend in the deformation and stress levels of the perforated aluminum panel. As the perforation rate increases, both the deformation and stress of the perforated aluminum panel show a trend of "initially decreasing and then increasing". The findings of this paper can provide technical support for the material selection, wind-resistant design, and application of perforated aluminum panels in practical engineering projects.